What question did this study set out to answer?

To assess the safety of controlled hypotensive epidural anesthesia and determine whether marked blood pressure reduction confers clinical risks or early benefits in older adults.

October 1, 1999AnesthesiologyOpen Access

Randomized Trial of Hypotensive Epidural Anesthesia in Older Adults

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Why the study?

Does a more markedly hypotensive range of epidural anesthesia improve early benefits or increase risks in elderly patients?

Population

Elderly patients

Comparison

Controlled hypotensive epidural anesthesia in a… vs Controlled hypotensive epidural anesthesia in a…

Design

RCT

Authors

PWPamela Williams‐RussoOclaro (Japan)NSNigel E. SharrockHospital for Special Surgery SMSteven MattisColorado State University

Discussion

Member takes

Implication

Supports less hypotensive epidural targets in elderly patients; confirms neutral early risk-benefit profile in RCT.

Key Points

To assess the safety of controlled hypotensive epidural anesthesia and determine whether marked blood pressure reduction confers clinical risks or early benefits in older adults.
Conducted a randomized trial evaluating a controlled hypotensive epidural anesthesia protocol in elderly surgical patients.
Compared outcomes between standard hemodynamic management and a more markedly hypotensive target range.
Controlled hypotensive epidural anesthesia was safely administered to elderly surgical patients under the defined protocol.
Targeting a markedly hypotensive range produced no evidence of increased adverse clinical risks compared with less intensive targets.
Use of the more pronounced hypotensive range provided no evidence of early postoperative clinical benefits.

Structured PICO

Does a more markedly hypotensive range of epidural anesthesia improve early benefits or increase risks in elderly patients?

Population

Elderly patients

Intervention

Controlled hypotensive epidural anesthesia in a more markedly hypotensive range

Comparator

Controlled hypotensive epidural anesthesia in a standard or less hypotensive range

Outcome

Risks and early benefitssafety

A more markedly hypotensive range during epidural anesthesia in elderly patients does not confer early benefits nor increase risks.

Cite This Study

Williams‐Russo et al. (1999) studied this question.

synapsesocial.com/papers/69ea306afc82ffee40a819d4 https://doi.org/10.1097/00000542-199910000-00011

Topics

Women and heart disease

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Randomized Trial of Hypotensive Epidural Anesthesia in Older Adults

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Randomized Trial of Hypotensive Epidural Anesthesia in Older Adults

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider