What is the clinical evidence from this study?

Population: Myocardial Infarction. Intervention: 18-fluorodeoxyglucose ((18)FDG) PET/MRI. Primary outcome: Monocyte recruitment in the remote myocardium (5.6-fold increase, p=<0.01).

What question did this study set out to answer?

This research aims to explore the role of inflammation in myocardial healing following an infarction.

April 23, 2026Journal of the American College of CardiologyOpen Access

PET/MRI of Inflammation in Myocardial Infarction

Q: What are the key findings of this study?

18-fluorodeoxyglucose PET/MRI demonstrated significant monocyte recruitment in the remote nonischemic myocardium after myocardial infarction (5.6-fold increase; p<0.01).

Q: What question did this study set out to answer?

This research aims to explore the role of inflammation in myocardial healing following an infarction.

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Key result

18FDG PET/MRI demonstrates a ~5.6-fold increase in monocyte recruitment in remote myocardium after MI.

5.6-fold increase
P<0.01

Why the study?

Clinical tools to assess innate immune cells in tissue are scarce, and it is unknown whether the nonischemic remote zone recruits monocytes after MI.

Population

Mice with coronary ligation and patients with acute MI

Authors

WLWon Woo LeeSeoul National University of Science and Technology BMBrett MarinelliMemorial Sloan Kettering Cancer Center ALAnja M. van der LaanInterventional Cardiology

Discussion

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Implication

Should not yet change post-MI clinical practice; leaves open remote inflammation as therapeutic target in remodeling.

Key Points

This research aims to explore the role of inflammation in myocardial healing following an infarction.
Mice underwent coronary ligation and inflammation was monitored through imaging and various assays.
Fluorescence-activated cell sorting and polymerase chain reaction were used for cellular analysis.
Histological techniques evaluated inflammatory cell recruitment.
Gd-DTPA-enhanced infarcts had high 18FDG uptake on day 5 after myocardial infarction (p < 0.01).
Monocyte recruitment in remote myocardium was approximately 10(4)/mg, indicating a 5.6-fold increase (p < 0.01).
There was a notable increase in inflammatory markers in remote myocardium post-infarction.

Structured PICO

Population

Mice with coronary ligation (myocardial infarction model) and patients with acute myocardial infarction

Intervention

18-fluorodeoxyglucose (18FDG) positron emission tomography/magnetic resonance imaging (PET/MRI)

Outcome

Myocardial inflammation (18FDG uptake, monocyte/macrophage recruitment, and inflammatory markers) in infarcted and remote myocardiumsurrogate

Main Result

Effect estimate: 5.6-fold increase

p-value: p=<0.01

18FDG PET/MRI demonstrates significant monocyte recruitment and inflammation in the remote nonischemic myocardium after myocardial infarction, which may contribute to post-MI dilation.

Cite This Study

Lee et al. (2012) studied Myocardial Infarction. 18-fluorodeoxyglucose ((18)FDG) PET/MRI was evaluated on Monocyte recruitment in the remote myocardium (5.6-fold increase, p=<0.01). 18-fluorodeoxyglucose PET/MRI demonstrated significant monocyte recruitment in the remote nonischemic myocardium after myocardial infarction (5.6-fold increase; p<0.01).

synapsesocial.com/papers/69ea3867c2ceeb8fbfae7e7b https://doi.org/10.1016/j.jacc.2011.08.066

Topics

Myocarditis

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PET/MRI of Inflammation in Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

PET/MRI of Inflammation in Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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Topics

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