What question did this study set out to answer?

To review the distribution and downstream signaling pathways of insulin and IGF-1 receptors in the brain and examine how central insulin action coordinates systemic metabolism and neurological function.

June 14, 2014DiabetesOpen Access

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

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Authors

AKAndré Kleinridders HFHeather A. Ferris WCWeikang Cai

Discussion

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Overview

Narrative review demonstrates how central insulin signaling controls systemic metabolism and neuronal integrity, highlighting its role in neurodegenerative and metabolic disorders.

Key Points

To review the distribution and downstream signaling pathways of insulin and IGF-1 receptors in the brain and examine how central insulin action coordinates systemic metabolism and neurological function.
Synthesized molecular and physiological evidence concerning insulin and IGF-1 receptor signaling networks throughout the central nervous system.
Evaluated neurobiological mechanisms linking central insulin dysfunction to peripheral metabolic regulation, synaptic integrity, and neurodegenerative disease processes.
Central insulin receptor activation regulates key peripheral processes, including appetite, body temperature, white adipose tissue mass, reproductive capacity, and hepatic glucose output.
Impaired brain insulin signaling reduces synaptogenesis, alters neurotransmitter channel activity, disrupts mitochondrial function, and increases tau protein phosphorylation associated with Alzheimer disease.

Cite This Study

Kleinridders et al. (2014) studied this question.

synapsesocial.com/papers/69eaad0a7ebffcff75ccf6df https://doi.org/10.2337/db14-0568

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June 14, 2014DiabetesOpen Access

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

View Full Paper

Ask AI

Bookmark

Authors

AKAndré Kleinridders HFHeather A. Ferris WCWeikang Cai

Discussion

Member takes

Overview

Narrative review demonstrates how central insulin signaling controls systemic metabolism and neuronal integrity, highlighting its role in neurodegenerative and metabolic disorders.

Key Points

To review the distribution and downstream signaling pathways of insulin and IGF-1 receptors in the brain and examine how central insulin action coordinates systemic metabolism and neurological function.
Synthesized molecular and physiological evidence concerning insulin and IGF-1 receptor signaling networks throughout the central nervous system.
Evaluated neurobiological mechanisms linking central insulin dysfunction to peripheral metabolic regulation, synaptic integrity, and neurodegenerative disease processes.
Central insulin receptor activation regulates key peripheral processes, including appetite, body temperature, white adipose tissue mass, reproductive capacity, and hepatic glucose output.
Impaired brain insulin signaling reduces synaptogenesis, alters neurotransmitter channel activity, disrupts mitochondrial function, and increases tau protein phosphorylation associated with Alzheimer disease.

Cite This Study

Kleinridders et al. (2014) studied this question.

synapsesocial.com/papers/69eaad0a7ebffcff75ccf6df https://doi.org/10.2337/db14-0568

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