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April 24, 2026SHILAP Revista de lepidopterologíaOpen Access

Multiple strategies, one mission: mesenchymal stromal cell-based mechanisms of action in osteoarthritis

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Authors

MJMaid JunuzovićUniversity of Veterinary Medicine ViennaATAntonia TroilletJBJanina BurkUniversity of Veterinary Medicine Vienna

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Overview

This review highlights mesenchymal stromal cell mechanisms that promote cartilage repair in osteoarthritis, suggesting therapeutic potential.

Key Points

  • To explore the mechanisms through which mesenchymal stromal cells act to address cartilage degeneration in osteoarthritis.
  • Review current literature on mesenchymal stromal cells and their effects on joint tissues.
  • Examine indirect mechanisms such as paracrine signaling and mitochondrial transfer.
  • Highlight the roles of MSCs in modulating immune responses within the joint.
  • Evidence suggests that MSCs primarily exert effects through indirect mechanisms.
  • Mitochondrial transfer is identified as a key emerging mechanism for joint tissue regeneration.
  • MSCs impact various cell types in the joint, promoting homeostasis and tissue repair.

Cite This Study

Junuzović et al. (2026) studied this question.

synapsesocial.com/papers/69eb07a4553a5433e34b31c9https://doi.org/10.3389/fcell.2026.1763344
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