Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 24, 2026Nature CommunicationsOpen Access

Zinc-redox crosstalk regulates proteostasis in the endoplasmic reticulum

View Full Paper
Ask AI
Bookmark
Share

Authors

YAYuta AmagaiCAChihiro AraiWYWakana Yamamoto

Discussion

Loading...

Member takes

Overview

Inhibition of ZIP7 disrupts zinc homeostasis in the endoplasmic reticulum, suggesting its vital role in proteostasis.

Key Points

  • This research aims to clarify the mechanisms through which zinc homeostasis and redox balance affect proteostasis in the endoplasmic reticulum.
  • Inhibition of ZIP7 observed for its effects on zinc levels in the ER and subsequent ER stress.
  • In vitro assays tested the interactions of zinc with the Ero1α-PDI oxidative system and the role of ERp44.
  • Analysis of the impact of altered redox conditions on the folding of Notch1 and EGFR receptors.
  • ZIP7 inhibition raised labile Zn<sup>2+</sup> levels significantly in the ER.
  • High Zn<sup>2+</sup> concentrations disrupted the function of the chaperone ERp44 and impaired membrane receptor folding.
  • Altered redox environment due to excess zinc inhibited oxidative folding, affecting crucial membrane proteins.

Cite This Study

Amagai et al. (2026) studied this question.

synapsesocial.com/papers/69eb0803553a5433e34b34f7https://doi.org/10.1038/s41467-026-72250-w
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress2016 · 102 citations
  2. 2A robust and economical pulse-chase protocol to measure the turnover of HaloTag fusion proteins2019 · 53 citations
  3. 3A highly photostable and bright green fluorescent protein2022 · 311 citations
  4. 4The human zinc-binding cysteine proteome2024 · 49 citations