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April 24, 2026Advanced Functional Materials0 citations

Oral Mucosa‐on‐a‐Chip for Modeling Chemotherapy‐Induced Mucositis and Evaluating Drug Efficacy (Adv. Funct. Mater. 32/2026)

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YKY. KimYonsei UniversitySLSunghan LeeDongguk UniversityHOHyeop OhDongguk University Ilsan Hospital

Key Points

  • The aim is to create an oral mucosa-on-a-chip to study chemotherapy-induced mucositis and assess drug responses.
  • Developed a microfluidic platform that integrates stratified epithelium, lamina propria, and vascular layers.
  • Utilized this platform to model oral mucosa's physiological functions and study mucositis.
  • Evaluated the efficacy of drugs in a controlled environment resembling human oral tissue.
  • Successfully replicated the complex environment of human oral mucosa.
  • Showed that the platform can effectively model chemotherapy-induced mucositis.
  • Indicated potential for improved evaluation of drug responses compared to traditional animal models.

Abstract

Oral-Mucosa-on-a-Chip The cover illustrates an oral mucosa-on-a-chip that reconstructs the complex microenvironment of human oral mucosa. A stratified epithelium, lamina propria, and vascular layers are integrated within a microfluidic platform to reproduce key physiological functions. This platform enables investigation of chemotherapy-induced mucositis, supports drug response evaluation, and provides a promising alternative to conventional animal models in preclinical studies. More information can be found in the Research Article by Hyo-Il Jung, Bongseop Kwak, Bo Hae Kim, and co-workers (10.1002/adfm.202521887).

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Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69eb084f553a5433e34b357ehttps://doi.org/10.1002/adfm.75113
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