A Surprising Complication: Arterial Thrombosis in a Patient Receiving RAD-140 (Testolone)

RAD-140 is a selective androgen receptor modulator (SARM) that has anabolic effects similar to those of some androgenic steroids and hormones such as testosterone. The androgenic activity of SARMs can increase the risk for thrombosis through various mechanisms. Here, we discuss the case of a 48-year-old man with a history of hypogonadism receiving testosterone replacement therapy taking RAD-140 as a supplement for bodybuilding who presented with arterial thrombosis. The patient was evaluated for hereditary thrombophilic conditions; his test results returned negative. Concurrent use of RAD-140 and testosterone may increase the risk for arterial thrombosis, highlighting the need for clinical awareness of supplement-related adverse effects.