Investigates the link between RAD51 gene variants and breast cancer risk in women, suggesting further research is needed.
Background: Hereditary factors play a major role in breast cancer development, making it a serious global health concern for women.This study aimed to determine if RAD51 gene polymorphism rs1801320 (135 G>C) increases breast cancer risk in women in Thi-Qar Province, Iraq.Methods: Forty women with breast cancer and twenty healthy volunteers participated.Data from blood samples were analyzed using Chi-square tests and odds ratios for PCR-based genotyping.Results: The RAD51 gene variant rs1801320 did not show a significant association with breast cancer risk in this group.Larger studies are needed to confirm these findings.Conclusion: Both patients and controls commonly had the GG genotype.The GC and CC genotypes did not show a significant risk difference.Allele frequencies were also similar between groups.
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Nouri et al. (2025) studied this question.
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