Integrin Beta 4 Protein Expression Bimodally Predicts Sensitivity to CDK4/6 Inhibition and Resistance to Immunotherapy in Breast Cancer

Zhimin Zhu; L X Hu; Yan-Wen Ma; Qiong-Ni Zhu

doi:10.1155/tbj/7668096

January 1, 2026The Breast JournalOpen Access

Integrin Beta 4 Protein Expression Bimodally Predicts Sensitivity to CDK4/6 Inhibition and Resistance to Immunotherapy in Breast Cancer

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Key Points

To evaluate the role of ITGB4 protein expression as a biomarker in predicting treatment sensitivity in breast cancer.
Assessment of ITGB4 protein expression levels in breast cancer subtypes.
Evaluation of sensitivity to CDK4/6 inhibitors in luminal subtypes.
Analysis of immunotherapy resistance in triple-negative breast cancer (TNBC).
ITGB4 expression predicts sensitivity to CDK4/6 inhibitors in luminal breast cancer subtypes.
High ITGB4 levels indicate resistance to immunotherapy in TNBC.
ITGB4 serves as a critical biomarker for personalized therapy.

Implication

Bimodal biomarker ITGB4 predicts treatment response in breast cancer, indicating tailored therapies.

Abstract

ITGB4 protein expression serves as a bimodal biomarker in breast cancer, predicting CDK4/6 inhibitor sensitivity in luminal subtypes while indicating immunotherapy resistance in TNBC. ITGB4 protein thus represents a critical biomarker for guiding personalized therapy in precision oncology.

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Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69eb08ef553a5433e34b3a0c https://doi.org/10.1155/tbj/7668096

View Full Paper

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Integrin Beta 4 Protein Expression Bimodally Predicts Sensitivity to CDK4/6 Inhibition and Resistance to Immunotherapy in Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Integrin Beta 4 Protein Expression Bimodally Predicts Sensitivity to CDK4/6 Inhibition and Resistance to Immunotherapy in Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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