Demonstrates visible-light-catalyzed bromination and chlorination in spiro-dihydroquinazolinones, implying effective halogenation methods.
Visible‐light‐catalyzed aromatization‐driven deconstructive bromination and chlorination of spiro‐dihydroquinazolinones are described, with perhalogenated methanes serving as halogenating agents. A series of remotely and site‐specifically bromoalkyl‐ and chloroalkyl‐substituted quinazolin‐4(3H)‐ones were obtained with moderate yields and functional‐group tolerance. A radical pathway involving nitrogen‐centered‐radical‐induced C─C bond cleavage and carbon–halogen bond formation is proposed for this transformation.
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Yan et al. (2026) studied this question.
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