Electrochemical Oxidation Ring-Opening of Spiro-Dihydroheteroaromatics with N -(Arylsulfonyl)acrylamides to Form Quinazolinone-Containing Long-Chain Amides

An electrochemically driven cascade oxidative reaction was developed using spiro-dihydroquinazolinones and activated alkenes, involving N-centered radical cation-induced C-C bond cleavage, C-C bond formation, and subsequent Truce-Smiles rearrangement. This aromatic-driven deconstruction functionalization strategy efficiently generates valuable long-chain amides containing quinazolinones with α-full-carbon tetrahedral centers. This protocol features mild reaction conditions, good functional group compatibility, and high reaction efficiency for achieving bifunctionalization of activated alkenes.