In vitro and in vivo activity of daptomycin plus ceftaroline for the treatment of experimental endocarditis due to Enterococcus faecalis with and without high-level aminoglycoside resistance

Key Points

• This research investigates the effectiveness of daptomycin combined with ceftaroline for treating endocarditis caused by Enterococcus faecalis, focusing on cases with and without aminoglycoside resistance.
• Conducted in vitro assessments of antibiotic combinations against Enterococcus faecalis.
• Evaluated in vivo efficacy using a model of endocarditis.
• Compared outcomes with and without high-level aminoglycoside resistance.
• The combination of daptomycin and ceftaroline demonstrates notable effectiveness against Enterococcus faecalis.
• In vitro results indicate enhanced antibacterial activity compared to individual drugs.
• In vivo results support the potential clinical utility of this combination therapy.