Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles

Wenyang Jing; Heewon Noh; Tuan Tan; Nicholas C. Wu; Hee-Sun Han

doi:10.1039/d6lc00098c

January 1, 2026Lab on a ChipOpen Access

Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles

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Key Points

The research aims to understand the dewetting dynamics in double emulsions to enhance giant unilamellar vesicle (GUV) production.
Examined double emulsions to observe dewetting behavior.
Analyzed various lipid, aqueous, and fluidic parameters.
Developed a physics-based framework for GUV assembly optimization.
Identified predictive rules for efficient GUV production.
Demonstrated that altering lipid and fluidic parameters affects vesicle stability and size.
Established systematic guidance for enhancing GUV assembly.

Implication

Systematic investigation reveals key dynamics for producing stable giant unilamellar vesicles, suggesting a new method for tunable assembly.

Abstract

Decoding dewetting dynamics in double emulsions establishes predictive rules for robust, tunable GUV assembly. This physics-based framework provides systematic guidance to optimize GUV production across varied lipid, aqueous, and fluidic parameters.

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Cite This Study

Jing et al. (2026) studied this question.

synapsesocial.com/papers/69eb0a66553a5433e34b475c https://doi.org/10.1039/d6lc00098c

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Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles

Key Points

Implication

Abstract

Discussion

Cite This Study

Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles

Key Points

Implication

Abstract

Discussion

Cite This Study

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