Discovery of Active Compounds in Qigui Jiangzhi Formula for Metabolic Dysfunction‐Associated Steatotic Liver Disease by a Multidimensional Phenotypic Analysis

Xianghao Xu; Fanxing Zhou; Zhe Wu; Yi Zhou; Yanying Zhang; Miao Xu; Xudong Xing; Ping Li; Guangji Wang; Hua Yang

doi:10.1002/pca.70075

April 22, 2026Phytochemical Analysis

Discovery of Active Compounds in Qigui Jiangzhi Formula for Metabolic Dysfunction‐Associated Steatotic Liver Disease by a Multidimensional Phenotypic Analysis

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Key Points

The aim is to identify active compounds in Qigui Jiangzhi Formula that target metabolic dysfunction-associated steatotic liver disease.
Proposed a multidimensional phenotypic analysis to overcome single-indicator limitations.
Identified key pathways involved in improving metabolic dysfunction.
Analyzed the active compounds present in Qigui Jiangzhi Formula.
Identified multiple active compounds that effectively target MASLD.
Established the key pathways through which these compounds exert their effects.
Demonstrated the superiority of the multidimensional approach over traditional methods.

Implication

Multidimensional phenotypic analysis identifies active compounds and pathways in MASLD, suggesting improved treatment options.

Abstract

This study overcame the limitations of single-indicator screening methods for MASLD by proposing a multidimensional phenotypic method. Using this method, the active compounds in QGJZF and the key pathways through which they improve MASLD were identified.

Discussion

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69eb0a94553a5433e34b49d8 https://doi.org/10.1002/pca.70075

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Discovery of Active Compounds in Qigui Jiangzhi Formula for Metabolic Dysfunction‐Associated Steatotic Liver Disease by a Multidimensional Phenotypic Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Discovery of Active Compounds in Qigui Jiangzhi Formula for Metabolic Dysfunction‐Associated Steatotic Liver Disease by a Multidimensional Phenotypic Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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