Key result
Youth obesity is linked to early β-cell dysfunction despite normal fasting glucose, influenced by puberty.
Observational
Early β-cell dysfunction occurs in overweight and obese youth before the onset of abnormal fasting glucose, highlighting the importance of considering pubertal stage and adiposity in metabolic assessments.
Our findings suggest that differences in β-cell function may be present even in the context of normal fasting glucose, indicating that glycaemia alone may not fully capture early variations in glucose-insulin dynamics. Since pubertal stage and adiposity significantly influenced these results, incorporating development- and weight-specific considerations may improve the interpretation of metabolic markers during growth. These findings support the need for more nuanced approaches to characterise metabolic variability in youth.
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Correa‐Burrows et al. (2026) conducted an observational in Overweight and obesity. Overweight and obesity was evaluated on β-cell function and glucose-insulin dynamics. Early β-cell dysfunction may be present in children and adolescents with overweight and obesity despite normal fasting glucose, and is significantly influenced by pubertal stage and adiposity.
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