What question did this study set out to answer?

To determine whether beta-cell hyperresponsiveness and insulin resistance in youth compared with adults are caused by increased glucagon secretion.

June 15, 2021Diabetes CareOpen Access

Hyperglucagonemia Does Not Explain the β-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study

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To determine whether beta-cell hyperresponsiveness and insulin resistance in youth compared with adults are caused by increased glucagon secretion.
Assessed 66 youth and 350 adults with impaired glucose tolerance or recently diagnosed, drug-naive type 2 diabetes.
Performed oral glucose tolerance tests and hyperglycemic clamps with arginine stimulation to evaluate insulin sensitivity, C-peptide, and glucagon dynamics.
Fasting glucagon (7.63 ± 3.47 vs. 8.55 ± 4.47 pmol/L; P = 0.063) and steady-state glucagon (2.24 ± 1.46 vs. 2.49 ± 1.96 pmol/L; P = 0.234) did not differ between youth and adults, while arginine-stimulated glucagon was lower in youth (14.1 ± 5.2 vs. 16.8 ± 8.8 pmol/L; P = 0.001).
Despite similar fasting glucagon levels, youth demonstrated higher fasting C-peptide and lower insulin sensitivity than adults, with age differences remaining independent of glucagon concentrations.

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Implication

Comparative study reveals youth with dysglycemia do not have elevated glucagon compared to adults, suggesting alpha-cell dysfunction does not drive their severe insulin resistance.

Cite This Study

Kahn et al. (2021) studied this question.

synapsesocial.com/papers/6a6e07a35d37378ac1dbc408 https://doi.org/10.2337/dc21-0460

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Implication

Comparative study reveals youth with dysglycemia do not have elevated glucagon compared to adults, suggesting alpha-cell dysfunction does not drive their severe insulin resistance.

Hyperglucagonemia Does Not Explain the β-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study

Key Points

Discussion

Implication

Cite This Study

Hyperglucagonemia Does Not Explain the β-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study

Key Points

Discussion

Implication

Cite This Study

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