Strategies to Overcome Hepatic Clearance of Endogenous Proteins – Molecular and Formulation Approaches

Key Points

• This review aims to identify and evaluate methods for improving the pharmacokinetics of therapeutic proteins by addressing hepatic clearance.
• Review of various formulation strategies for therapeutic proteins
• Assessment of hepatic clearance mechanisms
• Analysis of molecular approaches for enhancing drug circulation
• Identified key formulation strategies that can prolong circulation time of biologics
• Discussed molecular approaches that may reduce hepatic clearance
• Highlighted potential impacts on the therapeutic efficacy of proteins