This research aims to investigate the effectiveness of BP-Au@MnO2-Ce6 nanocomposites in photodynamic therapy under hypoxic conditions.
Utilized BP-Au@MnO2-Ce6 nanocomposites as a photosensitizer.
Conducted experiments under controlled hypoxia-related conditions.
Assessed the production of singlet oxygen and tumor cell viability.
Enhanced production of singlet oxygen was observed under hypoxia.
Tumor cell death increased significantly compared to traditional methods.
The nanocomposites improved overall photodynamic performance.
Abstract
As a widely used antitumor method, Photodynamic Therapy (PDT) mainly kills tumor cells through the toxic singlet oxygen ( 1 O 2 ) generated by the mixed action of photosensitizer, oxygen, and light source....