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April 21, 2026Journal of Addictive Diseases

Cytotoxic lesion of the corpus callosum after gamma hydroxybutyrate withdrawal: a case report

Kuang Heng Wang Kuei Hong Kuo Hsien Hsueh Shih Yi Ju Pan

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Key Points

The aim is to explore the neurotoxic effects of gamma hydroxybutyrate withdrawal as indicated by specific lesions.
Case report detailing clinical observations and radiological findings during GHB withdrawal.
Radiological evidence of cytotoxic lesions in the corpus callosum was noted.
These lesions suggest potential neurotoxic effects associated with GHB withdrawal.

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Implication

Case report reveals radiological indicators of neurotoxicity in GHB withdrawal, suggesting serious implications.

Abstract

CLOCCs may represent an important radiological indicator of GHB withdrawal-related neurotoxicity.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69eb0b25553a5433e34b4ea8 https://doi.org/10.1080/10550887.2026.2656693

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cytotoxic Lesions of the Corpus Callosum (CLOCCs) Related to Hypoglycemia: Clinical Insights and Pathogenesis2024 · 3 citations
2Cytotoxic Lesion of the Corpus Callosum in a Patient with Acute-on-Chronic Lithium Toxicity: A Case Reportcase_report · 2026 · 1 citations
3Cytotoxic lesions of the corpus callosum secondary to hypoxic brain injury in an adult: a case reportCase Report · 2026
4Cytotoxic Lesions of the Corpus Callosum Patterns and Etiologies: Insights from an Indian CohortOriginal Research · 2026 · 1 citations
5Cytotoxic lesion of corpus callosum associated with cerebral venous sinus thrombosisOriginal Research · 2026

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Boomerang Sign in the Corpus Callosum and Bilateral Cerebellar Peduncles: CLOCCs Plus — A Case Report2025
Extensive Osmotic Demyelination Syndrome With a Concomitant Cytotoxic Lesion of the Corpus Callosum in Hyperemesis Gravidarum: A Case Report2026
Cytotoxic Lesions of the Corpus Callosum (CLOCC) in Siblings: A Case Report2025

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