Effect of Huiyang Shengji unguent on the NOD-like receptor family pyrin domain containing protein 3/caspase1/ gasdermin D pathway and lymphatic angiogenesis in patients with diabetic foot ulcer.

Y U Fangning; L Li; Tang Xiao; H E Xiujuan; B Zhang; Yukun Chen; M A Yizhao; Zeyu Liu; Y E Jinsheng; X U Xuying

doi:10.19852/j.cnki.jtcm.2026.02.015

April 1, 2026

Effect of Huiyang Shengji unguent on the NOD-like receptor family pyrin domain containing protein 3/caspase1/ gasdermin D pathway and lymphatic angiogenesis in patients with diabetic foot ulcer.

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Key Points

To examine how Huiyang Shengji unguent influences the NLRP3/caspase-1/gasdermin D pathway and lymphatic angiogenesis to enhance wound healing in diabetic foot ulcers.
Analyzed the effects of Huiyang Shengji unguent on the NLRP3/caspase-1/gasdermin D pathway.
Investigated lymphangiogenesis in diabetic foot ulcer contexts.
Explored the implications for wound healing based on these cellular mechanisms.
Huiyang Shengji unguent inhibited cell necrosis linked to the NLRP3 pathway.
Promoted lymphangiogenesis, aiding in the regeneration of lymphatic vessels.
Supported the establishment of a protective field around wounds for better healing outcomes.

Implication

Uncovers how Huiyang Shengji unguent improves wound healing in diabetic foot ulcers, suggesting a novel therapeutic avenue.

Abstract

The mechanism of HYSJ to promote wound healing of the Yinsyndrome in patients with diabetic foot may involve inhibition of cell necrosis mediated by the NLRP3/caspase-1/gasdermin D pathway, promotion of lymphangiogenesis, and establishment of a "protective field" for wound healing.

Discussion

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Cite This Study

Fangning et al. (2026) studied this question.

synapsesocial.com/papers/69eb0b25553a5433e34b4f6b https://doi.org/10.19852/j.cnki.jtcm.2026.02.015

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Effect of Huiyang Shengji unguent on the NOD-like receptor family pyrin domain containing protein 3/caspase1/ gasdermin D pathway and lymphatic angiogenesis in patients with diabetic foot ulcer.

Key Points

Implication

Abstract

Discussion

Cite This Study

Effect of Huiyang Shengji unguent on the NOD-like receptor family pyrin domain containing protein 3/caspase1/ gasdermin D pathway and lymphatic angiogenesis in patients with diabetic foot ulcer.

Key Points

Implication

Abstract

Discussion

Cite This Study

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