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April 24, 2026The British Journal of Psychiatry6 citationsOpen Access

Schizophrenia and accelerated ageing: systematic review and future research directions

EFEmilio Fernández-EgeaCGClemente García‐RizoBKBrian Kirkpatrick

Key Points

  • This research aims to explore the relationship between schizophrenia and accelerated ageing, focusing on biological mechanisms.
  • Conducted a systematic review of existing literature.
  • Analyzed biological mechanisms associated with ageing in schizophrenia.
  • Identified telomere attrition as a significant factor in schizophrenia-related ageing.
  • Found evidence of oxidative and inflammatory stress contributing to biological ageing.

Abstract

Schizophrenia is associated with a multisystem ageing phenotype underpinned by convergent biological mechanisms, most consistently involving telomere attrition and oxidative and/or inflammatory stress. The overall pattern supports a model of advanced rather than uniformly accelerated ageing, reflecting early biological deviation with parallel rather than steeper decline.

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Cite This Study

Fernández-Egea et al. (2026) studied this question.

synapsesocial.com/papers/69eb0b50553a5433e34b5127https://doi.org/10.1192/bjp.2026.10606
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