What question did this study set out to answer?

To synthesize current evidence on biological mechanisms, clinical manifestations, and psychosocial factors associated with aging and accelerated decline in schizophrenia.

September 17, 2026GeriatricsOpen Access

Aging in Schizophrenia: Clinical, Biological, and Psychosocial Perspectives

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Authors

CMConstanza Morén APAlonso Pérez‐Toribio EREnric Rubio-Contreras

Discussion

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Overview

Integrative review uncovers evidence of accelerated biological, clinical, and psychosocial decline in older individuals with schizophrenia, highlighting the need for comprehensive care strategies.

Key Points

To synthesize current evidence on biological mechanisms, clinical manifestations, and psychosocial factors associated with aging and accelerated decline in schizophrenia.
Conducted an integrative review synthesizing clinical, biological, and psychosocial dimensions of the aging process in individuals with schizophrenia.
Evaluated intersecting contributions of cellular dysfunction, systemic comorbidities, polypharmacy, and psychosocial determinants of health.
Accelerated biological aging is driven by oxidative stress, mitochondrial dysfunction, chronic immune activation, and dysregulation of physiological stress-response systems.
Clinical presentation in older adults is dominated by high rates of cardiometabolic comorbidities, persistent cognitive impairment, and heightened functional dependency complicated by complex medication management.
Adverse psychosocial factors, including pervasive social isolation, stigma, and heavy caregiver burden, substantially worsen health trajectories and overall quality of life.

Cite This Study

Morén et al. (2026) studied this question.

synapsesocial.com/papers/6aabb68c5f706d05830e4fb3 https://doi.org/10.3390/geriatrics11050133

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September 17, 2026GeriatricsOpen Access

Aging in Schizophrenia: Clinical, Biological, and Psychosocial Perspectives

View Full Paper

Ask AI

Bookmark

Authors

CMConstanza Morén APAlonso Pérez‐Toribio EREnric Rubio-Contreras

Discussion

Member takes

Overview

Integrative review uncovers evidence of accelerated biological, clinical, and psychosocial decline in older individuals with schizophrenia, highlighting the need for comprehensive care strategies.

Key Points

To synthesize current evidence on biological mechanisms, clinical manifestations, and psychosocial factors associated with aging and accelerated decline in schizophrenia.
Conducted an integrative review synthesizing clinical, biological, and psychosocial dimensions of the aging process in individuals with schizophrenia.
Evaluated intersecting contributions of cellular dysfunction, systemic comorbidities, polypharmacy, and psychosocial determinants of health.
Accelerated biological aging is driven by oxidative stress, mitochondrial dysfunction, chronic immune activation, and dysregulation of physiological stress-response systems.
Clinical presentation in older adults is dominated by high rates of cardiometabolic comorbidities, persistent cognitive impairment, and heightened functional dependency complicated by complex medication management.
Adverse psychosocial factors, including pervasive social isolation, stigma, and heavy caregiver burden, substantially worsen health trajectories and overall quality of life.

Cite This Study

Morén et al. (2026) studied this question.

synapsesocial.com/papers/6aabb68c5f706d05830e4fb3 https://doi.org/10.3390/geriatrics11050133

View Full Paper

Ask AI

Bookmark