Aggregation polymorphism of photoactivatable Pt(IV) prodrugs as a strategy for the design of theranostic nanomaterials

Vladislav Bykusov; Ilya Kuzmichev; M. E. Stepanov; Dmitry Bunin; Yuriy N. Luponosov; Yulia Isaeva; Askold A. Trul; Roman Akasov; Tatiana Egorova; Alexander Erofeev; Regina Kuanaeva; Yulia Maksimova; Maxim Artemovich Abakumov; Aleksey A Nikitin; V. A. Kuz’min; Anton E. Egorov; Ivan Burtsev; И. А. Родин; Mikhail F. Vokuev; Елена К. Белоглазкина; Olga O. Krasnovskaya

doi:10.1039/d5dt02973b

Key Points

The aim is to explore how aggregation polymorphism in photoactivatable Pt(IV) prodrugs can enhance the design of theranostic nanomaterials.
Investigation of J-aggregates formed from Pt(IV) prodrugs
Evaluation of their applications in photothermal and photodynamic therapy
Assessment of multifunctional properties for therapeutic use
Enhanced efficiency of J-aggregates in photothermal and photodynamic therapy applications
Demonstrated potential of these nanomaterials in targeting serious diseases
Positive implications for future design strategies in theranostics

Implication

This research demonstrates the design of multifunctional theranostic nanomaterials, suggesting innovative strategies for serious diseases.

Abstract

The design of multifunctional theranostic nanomaterials, including the application of J-aggregates as photothermal (PTT) and photodynamic (PDT) therapy agents, is in high demand. Here, we report J-aggregates based on two...

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Cite This Study

Bykusov et al. (2026) studied this question.

synapsesocial.com/papers/69eb0b50553a5433e34b5137 https://doi.org/10.1039/d5dt02973b

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Aggregation polymorphism of photoactivatable Pt(IV) prodrugs as a strategy for the design of theranostic nanomaterials

Key Points

Implication

Abstract

Discussion

Cite This Study

Aggregation polymorphism of photoactivatable Pt(IV) prodrugs as a strategy for the design of theranostic nanomaterials

Key Points

Implication

Abstract

Discussion

Cite This Study

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