E3 ubiquitin ligase Peli3 regulates M2 macrophage-to-myofibroblast transition and fibrosis in wound healing via IRF4

Jinglin Zhu; Fangning Zhao; Gao Zeng

doi:10.1080/03008207.2026.2658059

April 22, 2026Connective Tissue Research

E3 ubiquitin ligase Peli3 regulates M2 macrophage-to-myofibroblast transition and fibrosis in wound healing via IRF4

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Key Points

To investigate how Peli3 regulates the transition of M2 macrophages and fibrosis in wound healing through IRF4.
Examined the role of Peli3 in M2 macrophage-to-myofibroblast transition.
Analyzed the effect of IRF4 stability on fibrosis progression via ubiquitination.
Peli3 promotes the stability of IRF4, influencing the MMT of M2 macrophages.
Inhibition of Peli3 leads to reduced fibrosis during wound healing.

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Implication

Demonstrates the role of Peli3 in regulating fibrosis and M2 macrophage transitions in wound healing, suggesting therapeutic targets for injury repair.

Abstract

IRF4 promotes M2 MMT and fibrosis progression, with its stability regulated by Peli3-mediated ubiquitination.

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Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69eb0b50553a5433e34b51a7 https://doi.org/10.1080/03008207.2026.2658059

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E3 ubiquitin ligase Peli3 regulates M2 macrophage-to-myofibroblast transition and fibrosis in wound healing via IRF4

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

E3 ubiquitin ligase Peli3 regulates M2 macrophage-to-myofibroblast transition and fibrosis in wound healing via IRF4

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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