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April 24, 2026Investigative Ophthalmology & Visual Science0 citationsOpen Access

Genetic Architecture of Trans-Laminar Cribrosa Pressure Difference and Primary Open-Angle Glaucoma

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IHIn-Shik HongSamsung Medical CenterCCChamlee ChoSamsung Medical CenterBKBeomsu KimBroad Institute

Key Points

  • The research focuses on identifying genetic factors associated with trans-laminar cribrosa pressure difference (TLCPD) in the context of primary open-angle glaucoma (POAG).
  • Analyzed genetic variants and associated genes in UKBB participants of European ancestry.
  • Investigated cell types and tissues linked to TLCPD.
  • Examined the relationship between TLCPD and POAG susceptibility.
  • Identified specific genetic variants associated with TLCPD.
  • Demonstrated a link between TLCPD and the risk of developing POAG.
  • Highlighted potential contributions of these variants to disease pathogenesis.

Abstract

This study identified TLCPD-associated variants, genes, cell types, tissues, and diseases in UKBB participants of European ancestry. These findings support the clinical relevance of TLCPD in glaucoma pathogenesis, implicating TLCPD-related genetic variants as contributor to POAG susceptibility.

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Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/69eb0bc7553a5433e34b5573https://doi.org/10.1167/iovs.67.4.51
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