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April 25, 2026Neuroscience & Biobehavioral ReviewsOpen Access

The neonatal brain at rest: a systematic review of task-free functional connectivity in the first 100 days

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Authors

LCLaura CarnevaliUniversity of PaduaLLLetizia Della LongaUniversity of PaduaTFTeresa FarroniUniversity of Padua

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Implication

Systematic review explores functional connectivity in neonates, indicating early brain development patterns.

Key Points

  • The aim is to synthesize findings on task-free functional connectivity in the neonatal brain during the first 100 days post-partum.
  • Reviewed 103 studies focused on functional connectivity in the resting neonatal brain.
  • Assessed evidence of brain network organization and interindividual variability.
  • Analyzed early development of cortical structure and function in relation to environmental influences.
  • Neonatal networks exhibit small-world topology with strong local clustering and long-range integration.
  • Sensorimotor, visual, and auditory hubs are predominant, while higher-order networks develop more slowly.
  • Significant interindividual variability in functional connections exists, influenced by both infant characteristics and context.

Cite This Study

Carnevali et al. (2026) studied this question.

synapsesocial.com/papers/69ec593e88ba6daa22dab42dhttps://doi.org/10.1016/j.neubiorev.2026.106703
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