CAM5.2 immunostaining visualizes hemodynamic-driven ductular-like differentiation in the liver:a practical marker for distinguishing circulatory disturbance–related hyperplastic lesions from hepatocellular tumors

Key Points

• This research aims to distinguish hyperplastic lesions from hepatocellular tumors using CAM5.2 immunostaining.
• CAM5.2 immunostaining technique applied to liver samples.
• Analysis of spatial patterns to identify hyperplastic lesions such as FNH.
• Assessment of ductular-like differentiation in hepatocytes.
• CAM5.2 effectively visualizes ductular reaction-like modulation in hepatocytes.
• Identified distinct patterns in cases of circulatory disturbance-related hyperplastic lesions.
• Differentiation between hyperplastic lesions and hepatocellular tumors, such as HCC and HCA, was supported by regular spatial patterns.