Preactivation-free direct decarboxylative alkynylation of indoleacetic acids: access to alkynyl-functionalized indoles

Key Points

• The research aims to develop a novel method for the decarboxylative alkynylation of indoleacetic acids using terminal alkynes without preactivation.
• Utilized transition-metal catalysis for the alkynylation process.
• Explored the reaction under mild conditions to achieve the desired products.
• Assessed various terminal alkynes in the reaction.
• Achieved successful alkynylation of indoleacetic acids with good yields.
• Demonstrated the reaction's efficiency compared to traditional methods.
• Provided access to a range of alkynyl-functionalized indoles.