Preactivation-free direct decarboxylative alkynylation of indoleacetic acids: access to alkynyl-functionalized indoles

Gui-Ting Song; Yuan Zhou; Xue-Ying Yang; Li-Min Zhang; Lan-Bin He; Li-Ping Qing; Cheng-Mi Lin; Zhuo-Er Chen; 屈川华

doi:10.1039/d6cc01731b

January 1, 2026Chemical Communications

Preactivation-free direct decarboxylative alkynylation of indoleacetic acids: access to alkynyl-functionalized indoles

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Key Points

The research aims to develop a novel method for the decarboxylative alkynylation of indoleacetic acids using terminal alkynes without preactivation.
Utilized transition-metal catalysis for the alkynylation process.
Explored the reaction under mild conditions to achieve the desired products.
Assessed various terminal alkynes in the reaction.
Achieved successful alkynylation of indoleacetic acids with good yields.
Demonstrated the reaction's efficiency compared to traditional methods.
Provided access to a range of alkynyl-functionalized indoles.

Implication

Demonstrates efficient alkynylation in indoleacetic acids, suggesting a new synthetic approach.

Abstract

Herein, we report, to the best of our knowledge, the first preactivation-free decarboxylative alkynylation of indoleacetic acids with terminal alkynes via transition-metal catalysis. This protocol operates under mild conditions, forges...

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Cite This Study

Song et al. (2026) studied this question.

synapsesocial.com/papers/69ec59fc88ba6daa22daba11 https://doi.org/10.1039/d6cc01731b

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Preactivation-free direct decarboxylative alkynylation of indoleacetic acids: access to alkynyl-functionalized indoles

Key Points

Implication

Abstract

Discussion

Cite This Study

Preactivation-free direct decarboxylative alkynylation of indoleacetic acids: access to alkynyl-functionalized indoles

Key Points

Implication

Abstract

Discussion

Cite This Study

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