Cervical cancer (CC) represents a significant public health challenge globally. This research sought to explore the effect of the microRNA (miR)-1307-3p in CC. 180 CC patients were recruited. The association between miR-1307-3p expression and patient survival was evaluated using the Kaplan-Meier method, while risk factors associated with patient mortality were identified by Cox regression analysis. Additionally, the expression of relevant genes was measured using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Cell viability was assessed using the cell counting kit-8 (CCK-8), and cell migration and invasion were analyzed using Transwell. Furthermore, the dual-luciferase reporter assay was performed to confirm the targeted regulatory relationship between miR-1307-3p and forkhead box O3 (FOXO3). MiR-1307-3p was significantly upregulated in CC tissues, and its high expression was closely associated with the malignant progression of CC. MiR-1307-3p promoted the malignant progression of CC by directly targeting and inhibiting the FOXO3 gene. Inhibition of miR-1307-3p significantly suppressed cell proliferation, migration, and invasion. However, knocking down FOXO3 partially reversed the aforementioned biological effects induced by the miR-1307-3p inhibitor. MiR-1307-3p was involved in promoting carcinogenesis during the occurrence and progression of CC.
Lu et al. (Thu,) studied this question.