Calcifying nested stromal epithelial tumor (CNSET) is a rare primary hepatic neoplasm characterized by nests of epithelial and spindle stromal cells with extensive calcification and ossification, predominantly affecting children and young adults with female predominance. Although calcifying nested stromal-epithelial tumor (CNSET) may appear radiologically aggressive, it usually exhibits low-grade malignant potential and carries an excellent prognosis following complete surgical resection. In this case report, we describe the course and outcome of a 17-year-old adolescent female who was referred to the hospital for an incidentally detected liver lesion. Magnetic resonance imaging (MRI) was taken for characterization of the liver lesion which showed a single well circumscribed lobulated lesion involving the right lobe of the liver with focal areas of necrosis and coarse calcifications within. Subsequently, ultrasound guided biopsy revealed an infiltrative tumor composed of epithelioid cells arranged in swirling nests and nodules, many of which contained centrally located osteoid-like material. Biopsy features were suggestive of calcifying nested stromal-epithelial tumor (CNSET). The possibility of this entity should be entertained in radiological differential diagnosis of a calcified liver mass in a young female.
Chigurupati et al. (Thu,) studied this question.