Key result
Pathological and ultrastructural examination of a testicular mass in a 7-year-old boy revealed a large cell calcifying Sertoli cell tumor with Spangaro's crystals and no signs of Carney syndrome.
Case Report (n=1)
This case report describes the rare occurrence and ultrastructural features of a large cell calcifying Sertoli cell tumor in a 7-year-old boy without Carney syndrome.
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May aid recognition of rare pediatric testicular tumors; extends ultrastructural data on Spangaro's crystals beyond Carney syndrome.
Large cell calcifying Sertoli cell tumor (LCCST) is a rare testicular tumor, usually occurring in young men before the age of 20. Ultrastructural study has been performed rarely demonstrating Sertoli cell features. We report a case of LCCST in a 7-year-old boy. A well-circumscribed yellowish-tan, 1.5-cm-sized mass was located within the left testicular parenchyma. The cut surface was somewhat resilient with multiple calcifications. On microscopic examination, the tumor was composed of large eosinophilic polygonal cells with abundant eosinophilic cytoplasm arranging in solid tubular and trabecular patterns, superficially mimicking Leydig cell tumor. However, there were multiple calcifications and the tumor cell nests were surrounded by PAS-positive basement membrane. Ultrastructural examination revealed the features of the Sertoli cell with Spangaro's crystals. The right testis showed a normal appearance by ultrasonogram and there were no other clinical features associated with Carney syndrome.
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Kie et al. (1999) conducted a case report in Large cell calcifying Sertoli cell tumor (LCCST) (n=1). Pathological and ultrastructural examination of a testicular mass in a 7-year-old boy revealed a large cell calcifying Sertoli cell tumor with Spangaro's crystals and no signs of Carney syndrome.
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