Key result
Testicular-sparing excisional biopsy successfully manages Carney complex Sertoli cell tumours, avoiding radical orchiectomy.
Why the study?
Large cell calcifying Sertoli cell tumours are extremely rare, and confirming the diagnosis is challenging to avoid radical intervention and preserve fertility potential in young males.
Case Report (n=1)
No
In young males presenting with bilateral multifocal large cell calcifying Sertoli cell tumours, combining clinical, radiological, histopathological, and genetic evaluation (for Carney complex via PRKAR1A testing) allows safe testicular-sparing surgery to preserve fertility and avoid radical orchiectomy.
Hypothesis-generating for PRKAR1A-guided sparing surgery in bilateral LCCSCT; leaves open broader adoption pending prospective data.
Testicular Large cell calcifying Sertoli cell tumours (LCCSTs) are extremely rare. The primary challenge in benign LCCSTs, which are typically multifocal and bilateral tumours affecting young males, is to confirm the diagnosis to avoid radical intervention and preserve fertility potential. Patient clinical presentation, laboratory results, diagnostic radiological tests along with confirmatory histopathological studies, are the cornerstones in such cases, nevertheless genetic testing is warranted, as LCCSTs can be part of genetic syndrome such Carney complex. We present a case of bilateral benign LCCSTs in young male managed with testicular preservation approach with characteristic clinical, radiological and histopathological features.
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Khalil et al. (2023) conducted a case report in Bilateral benign large cell calcifying Sertoli cell tumours (LCCSTs) associated with Carney complex (n=1). Testicular-sparing surgery (right inguinal excisional testicular biopsy with excision of four well-circumscribed lesions <1 cm) after sperm cryopreservation was evaluated on Histopathological diagnosis and testicular preservation. Testicular-sparing excisional biopsy confirmed benign bilateral large cell calcifying Sertoli cell tumours with a PRKAR1A mutation (Carney complex) in an 18-year-old male, avoiding radical orchiectomy.
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