Research on the regulation of osteogenic differentiation and mechanotransduction by porous bionic coatings on titanium alloy implant surfaces

Key Points

• The aim is to explore how porous bionic coatings affect osteogenic differentiation and mechanotransduction on titanium alloy implants.
• Porous biomimetic coating was fabricated on TA2 titanium alloy via MAO.
• Evaluation of BMSC adhesion and spreading on the coated surface.
• Analysis of implant-bone interfacial bonding strength.
• Porous structure significantly promoted BMSC adhesion and spreading.
• Activated mechanotransduction pathways were observed.
• Enhanced implant-bone interfacial bonding strength noted with the porous coating.