Association of epigenetic trajectory with development of clinical rheumatoid arthritis in anti‐citrullinated protein antibody positive individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis ( TIP ‐ RA )

E. Barton Prideaux; David L. Boyle; Eunice Choi; Jane H. Buckner; William H. Robinson; V Michael Holers; Kevin D. Deane; Gary S. Firestein; Wei Wang

doi:10.1002/art.70193

April 22, 2026Arthritis & Rheumatology

Association of epigenetic trajectory with development of clinical rheumatoid arthritis in anti‐citrullinated protein antibody positive individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis ( TIP ‐ RA )

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Key Points

The research aims to understand how changes in DNA methylation are linked to the progression of rheumatoid arthritis in individuals who are positive for anti-CCP3 antibodies.
Focused on individuals with anti-CCP3 antibodies during their progression to clinical arthritis.
Compared epigenetic changes in asymptomatic individuals, non-converters, and control groups.
Identified biomarkers associated with the transition from at-risk to clinical arthritis.
DNA methylation changes were significant in anti-CCP3-positive individuals moving toward clinical arthritis, with stable patterns observed in controls.
Progressive remodeling correlated with pathogenic pathways, suggesting potential biomarkers for disease prediction.
Findings indicate that epigenetic changes could guide preventive interventions for rheumatoid arthritis.

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Implication

Investigates epigenetic changes in anti-CCP3-positive individuals, suggesting pathways for preventive strategies.

Abstract

DNA methylation is a dynamic process that continuously remodels in asymptomatic anti-CCP3-positive individuals as they progress to disease, while remaining relatively stable in Non-converters and Controls. Progressive epigenetic remodeling during the trajectory from At-Risk to clinical arthritis highlights pathogenic pathways and yields biomarkers that may inform prognostic testing and preventive intervention in preclinical RA.

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Prideaux et al. (2026) studied this question.

synapsesocial.com/papers/69ec5a8888ba6daa22dac21a https://doi.org/10.1002/art.70193

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Association of epigenetic trajectory with development of clinical rheumatoid arthritis in anti‐citrullinated protein antibody positive individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis ( TIP ‐ RA )

Key Points

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Implication

Abstract

Discussion

Cite This Study

Association of epigenetic trajectory with development of clinical rheumatoid arthritis in anti‐citrullinated protein antibody positive individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis ( TIP ‐ RA )

Key Points

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Implication

Abstract

Discussion

Cite This Study

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