Observational analysis shows altered immune cell functions in rheumatoid arthritis, suggesting epigenetic factors influence disease progression.
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovial inflammation, joint destruction, and systemic features. Dysregulated immune cells—particularly T cells, B cells, and macrophages—drive its onset and progression. Epigenetic mechanisms, including DNA methylation, histone modifications, RNA editing, and non-coding RNAs, critically shape immune cell activation, differentiation, and effector functions, perpetuating autoimmunity and chronic inflammation.
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Cai et al. (2025) studied this question.
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