This study was carried out to determine the sub-chronic toxicity of stem bark ethanolic extract of Terminalia mantaly on Albino Rats. The plant extract was prepared by cold maceration of the powder in ethanol for 48 hours and filtered. Albino rats were obtained grouped into three groups of five rats each with the control group and administered the extracts for 28 days. On 29th day, blood was collected to determine the haematological and biochemical parameters. Later, the animals were sacrificed, liver and kidney were removed for histopathological analysis to determine the structural changes. The data obtained was analyzed using one way ANOVA and there was no much statistical significance difference when compared with the control. The result showed that there was 0 mortality recorded after administration of the extract from 300mg/kg to 500mg/kg on the animals after 28 days. Animals do not show any major sign of toxicity. The result on the biochemical and haematological indices determination were within the range values when compared with the control group. The histopathological examination of liver and kidney showed normal architectures with no differences in histological and cellular structures of all organs.
Usman et al. (Thu,) studied this question.