Malignant epithelioid mesenchymal neoplasms with EWSR1/FUS :: CREM fusions: clinicopathological and molecular genetic analysis of seven cases highlighting immunophenotypic heterogeneity, frequent aggressive behaviour, and diagnostic pitfalls

M Zhao; Jiayun Xu; Shiyu Zheng; Lin Ye; Yì Wáng

doi:10.1111/his.70165

April 23, 2026Histopathology

Malignant epithelioid mesenchymal neoplasms with EWSR1/FUS :: CREM fusions: clinicopathological and molecular genetic analysis of seven cases highlighting immunophenotypic heterogeneity, frequent aggressive behaviour, and diagnostic pitfalls

View Full Paper

Ask AI

Bookmark

Share

Key Points

This analysis aims to characterize epithelioid mesenchymal neoplasms with EWSR1/FUS::CREM fusions regarding their clinicopathological and molecular features.
Analyzed seven cases of epithelioid mesenchymal neoplasms
Employed clinicopathological and molecular genetic techniques
Discussed immunophenotypic findings and diagnostic challenges
All cases exhibited aggressive clinical behavior with frequent metastatic potential
Identified misleading immunophenotypic traits complicating diagnosis
Emphasized the necessity of molecular testing for accurate diagnosis

Implication

Case series reveals aggressive behaviour and diagnostic challenges in epithelioid mesenchymal neoplasms with EWSR1/FUS CREM fusions.

Abstract

Our series solidifies epithelioid mesenchymal neoplasms with EWSR1/FUS::CREM fusions, which constitute a distinct sarcoma characterized by a misleading immunophenotype, with potential for aggressive clinical behaviour. Accurate diagnosis requires molecular confirmation to avoid diagnostic pitfalls and guide management.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69ec5ac988ba6daa22dac5d4 https://doi.org/10.1111/his.70165

View Full Paper

Ask AI

Bookmark

Share

Malignant epithelioid mesenchymal neoplasms with EWSR1/FUS :: CREM fusions: clinicopathological and molecular genetic analysis of seven cases highlighting immunophenotypic heterogeneity, frequent aggressive behaviour, and diagnostic pitfalls

Key Points

Implication

Abstract

Discussion

Cite This Study

Malignant epithelioid mesenchymal neoplasms with EWSR1/FUS :: CREM fusions: clinicopathological and molecular genetic analysis of seven cases highlighting immunophenotypic heterogeneity, frequent aggressive behaviour, and diagnostic pitfalls

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading