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April 25, 2026JAMA Oncology2 citations

Identifying High-Risk Smoldering Multiple Myeloma for Early Intervention

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CMCecilie V. MaengSRSæmundur RögnvaldssonCBChristian Brieghel

Key Points

  • This research aims to determine the effectiveness of different models in identifying high-risk smoldering multiple myeloma (SMM) patients.
  • Cohort study comparing the AQUILA trial criteria with the 2/20/20 model.
  • Assessment of patient classification rates between models.
  • Analysis of progression risks associated with each model.
  • AQUILA trial criteria identified approximately three times more patients as high-risk compared to the 2/20/20 model.
  • The 2/20/20 model captured a subgroup with significantly lower progression risk.
  • Findings suggest the 2/20/20 model more accurately identifies truly high-risk SMM patients for potential early intervention.

Abstract

This cohort study found that the AQUILA trial criteria classified approximately 3 times more patients with SMM as having high risk compared with the 2/20/20 model and captured a group with substantially lower progression risk. These results suggest that the 2/20/20 model more accurately identifies a truly high-risk group with SMM, for whom early treatment is more likely to be beneficial.

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Cite This Study

Maeng et al. (2026) studied this question.

synapsesocial.com/papers/69ec5ae988ba6daa22dac66fhttps://doi.org/10.1001/jamaoncol.2026.0831
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Smoldering Multiple Myeloma: From Clinical to Immunogenomic Risk Stratification and Therapeutic Implications of Early Intervention2026
  2. 2High-risk smoldering myeloma – a case for early intervention?2025
  3. 3The Difficulty in Defining the True High-Risk Smoldering Myeloma2024
  4. 4High-Risk Smoldering Multiple Myeloma: A Review of Controversies in Early Treatment Versus Observation2026
  5. 5Smoldering Multiple Myeloma: Early Intervention or Structured Surveillance? A Comprehensive Review of Evidence for and Against Early Therapy2026