Shows efficient chiral alkylation in 3-hydroxyoxindoles, suggesting new pathways for asymmetric synthesis.
A light-promoted asymmetric alkylation reaction of 3-hydroxyoxindoles with NHPI esters was realized using a chiral guanidine organocatalyst, without a photocatalyst, offering chiral 3,3′-bifunctional oxindoles with high efficiency.
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Song et al. (2026) studied this question.
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