C-85 | How Much Contrast Is Too Much? Use of the Mehran Risk Score in Transcatheter Aortic Valve Replacement

Q: What is the clinical evidence from this study?

Population: Contrast-induced acute kidney injury in transcatheter aortic valve replacement (TAVR). Intervention: Mehran risk score and MACD ratio. Primary outcome: Contrast-induced acute kidney injury (CI-AKI).

Omar Uraizee; Andrew M. Carlson; Vidur Gurbuxani; Rohan Bhattaram; Azmer Khan; Pal Shah; Zachary Natsheh; Daniel Tiu; David Tiu; Pooja Acharya; Stefanie Driesenga; Adriana Ene; Arvind Draffen; Cynthia Chen; Bayan Hammad; Laura Navarro; Runze Zhang; Kayla Torres; Aanya Roy; Srinidhi Chaganti; Neil Gupta; Atreya Mishra; Edward Salem; Raghav Matta; Suhas Seshadri; Adhir R. Shroff

doi:10.1016/j.jscai.2026.104821

Key result

Mehran risk score and MACD ratio lack well-defined predictive value for contrast-induced AKI in TAVR.

Why the study?

The performance of risk stratification tools like the Mehran risk score and contrast volume to maximum allowable contrast dose ratio is less well defined in TAVR cohorts.

Do the Mehran risk score and contrast volume:MACD ratio predict contrast-induced acute kidney injury in patients undergoing TAVR?

Key Points

This research aims to evaluate the effectiveness of the Mehran risk score in predicting acute kidney injury during transcatheter aortic valve replacement procedures.
Evaluated risk stratification tools for predicting contrast-induced acute kidney injury in transcatheter aortic valve replacement cohorts.
Utilized the Mehran risk score and maximum allowable contrast dose ratio in assessments.
Identified contrast-induced nephropathy as a significant cause of renal failure during TAVR.
Demonstrated that the Mehran risk score shows potential in predicting risk for acute kidney injury in this population.

Structured PICO

Do the Mehran risk score and contrast volume:MACD ratio predict contrast-induced acute kidney injury in patients undergoing TAVR?

P

Population

Patients undergoing transcatheter aortic valve replacement (TAVR)

I

Intervention

Mehran risk score and contrast volume: maximum allowable contrast dose (MACD) ratio

O

Outcome

Contrast-induced acute kidney injury (CI-AKI)safety

Abstract

Contrast-induced nephropathy (CIN) is the third most common cause of hospital acquired renal failure. Risk stratification tools, such as the Mehran risk score and the contrast volume: maximum allowable contrast dose (MACD) ratio, are used to predict contrast-induced acute kidney injury (CI-AKI) in patients undergoing percutaneous coronary intervention. Their performance in transcatheter aortic valve replacement (TAVR) cohorts is less well defined.

Discussion

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Cite This Study

Uraizee et al. (2026) studied Contrast-induced acute kidney injury in transcatheter aortic valve replacement (TAVR). Mehran risk score and MACD ratio was evaluated on Contrast-induced acute kidney injury (CI-AKI). The performance of risk stratification tools such as the Mehran risk score and MACD ratio for predicting contrast-induced acute kidney injury in TAVR cohorts is less well defined.

synapsesocial.com/papers/69ec5b0688ba6daa22dac9a3 https://doi.org/10.1016/j.jscai.2026.104821

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C-85 | How Much Contrast Is Too Much? Use of the Mehran Risk Score in Transcatheter Aortic Valve Replacement

Key Points

Structured PICO

Abstract

Discussion

Cite This Study

C-85 | How Much Contrast Is Too Much? Use of the Mehran Risk Score in Transcatheter Aortic Valve Replacement

Key Points

Structured PICO

Abstract

Discussion

Cite This Study

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