Key result
Higher contrast volume to eGFR ratio during TAVR predicts AKI.
Why the study?
The role of contrast volume in the context of baseline renal function as a predictor of acute kidney injury is less well described in patients undergoing TAVR.
Does the ratio of contrast volume to estimated glomerular filtration rate predict acute kidney injury in patients undergoing transcatheter aortic valve replacement?
Population
Patients from the Michigan TAVR registry between January 2016 and December 2019
Comparison
Ratio of contrast volume to estimated glomerular filtration rate
Design
Registry-based cohort study
Authors
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May support contrast minimization in TAVR to lower AKI risk; leaves open whether ratio-guided interventions improve outcomes.
Cohort
Yes
Does the ratio of contrast volume to estimated glomerular filtration rate predict acute kidney injury in patients undergoing transcatheter aortic valve replacement?
p-value: p=<0.0001
The ratio of contrast volume to eGFR is a robust predictor of acute kidney injury following TAVR, suggesting thresholds of >2× and >3× eGFR should be incorporated into procedural planning.
Gualano et al. (2022) conducted a cohort in Transcatheter aortic valve replacement (TAVR). Ratio of contrast volume to estimated glomerular filtration rate (CV/eGFR) was evaluated on Acute kidney injury (AKI) (95% CI 1.38-2.03, p=<0.0001). The ratio of contrast volume to estimated glomerular filtration rate during TAVR significantly predicted acute kidney injury (95% CI 1.38-2.03; P<0.0001).
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