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December 17, 2017Clinical and investigative medicineOpen Access

Predicting Acute Kidney Injury following Transcatheter Aortic Valve Replacement

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Key result

A patient's previous renal response to contrast administered during coronary angiogram was not predictive of their change in renal function post-TAVR (r=0.043, P=0.582).

Why the study?

Does the change in GFR following pre-TAVR coronary angiography predict the change in renal function post-TAVR in patients undergoing TAVR?

Population

195 patients who underwent transcatheter aortic valve replacement at a single center between August 2008 and…

Design

Cohort

Authors

JMJeffrey A. MarbachJFJoshua D. FederAYAltayyeb Yousef

Discussion

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Overview

Prior contrast response should not guide post-TAVR renal risk assessment; leaves open validation of alternative predictors in prospective cohorts.

Study Design

Type

Cohort (n=195)

Multicenter

No

Structured PICO

Does the change in GFR following pre-TAVR coronary angiography predict the change in renal function post-TAVR in patients undergoing TAVR?

P
Population
195 patients who underwent TAVR at a single center between August 2008 and June 2015.
E
Exposure
Change in glomerular filtration rate (ΔGFR) in response to contrast administered during pre-TAVR coronary angiography
O
Outcome
Change in renal function (ΔGFR) post-TAVRsafety

Main Result

Effect estimate: r=0.043

p-value: p=0.582

A patient's renal response to contrast during pre-TAVR coronary angiography does not predict post-TAVR acute kidney injury; baseline renal function and contrast volume remain the most important predictors.

Cite This Study

Marbach et al. (2017) conducted a cohort in Transcatheter aortic valve replacement (TAVR) (n=195). Change in glomerular filtration rate (ΔGFR) post-angiogram was evaluated on Change in renal function post-TAVR (ΔGFR post-TAVR) (r=0.043, p=0.582). A patient's previous renal response to contrast administered during coronary angiogram was not predictive of their change in renal function post-TAVR (r=0.043, P=0.582).

synapsesocial.com/papers/6ab87d4acaef18e802b187a5https://doi.org/10.25011/cim.v40i6.29125
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal Function–Based Contrast Threshold Predicts Kidney Injury in Transcatheter Aortic Valve Replacement2022 · 13 citations
  2. 2Changes in kidney function among patients undergoing transcatheter aortic valve replacement2017 · 5 citations
  3. 3Prognostic value of renal function in patients with aortic stenosis treated with transcatheter aortic valve replacement2016 · 15 citations
  4. 4Perioperative renal function change after transcatheter aortic valve replacement: A single-center retrospective study in China2023
  5. 5Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement2021 · 10 citations