Key result
Both acute kidney recovery (17.8%) and acute kidney injury (14.6%) following TAVR were associated with increased cardiovascular mortality compared to unchanged renal function (8.1%; p<0.022).
Why the study?
While acute kidney injury carries a dismal prognosis in TAVR, acute kidney recovery has recently been linked to better outcomes, prompting further investigation of these post-procedural renal changes.
Does acute kidney injury or acute kidney recovery impact cardiovascular mortality in patients undergoing TAVR?
Population
574 consecutive patients referred for TAVR
Comparison
AKI vs AKR vs unchanged renal function post-TAVR
Design
Observational cohort study
Follow-up
Median 608 days (range 355-893)
Authors
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AKI and AKR after TAVR were associated with higher CV mortality; hypothesis-generating for renal monitoring and requires prospective validation.
Cohort (n=574)
No
Does acute kidney injury or acute kidney recovery impact cardiovascular mortality in patients undergoing TAVR?
Hazard Ratio: 2.26 (95% CI 1.14–4.88)
Absolute Event Rate: 17.8% vs 8.1%
p-value: p=0.021
Both acute kidney injury and acute kidney recovery following TAVR are associated with increased long-term cardiovascular mortality.
Peillex et al. (2021) conducted a cohort in Transcatheter Aortic Valve Replacement (n=574). Acute kidney injury (AKI) and acute kidney recovery (AKR) vs. Unchanged renal function was evaluated on Cardiovascular mortality (HR 2.26, 95% CI 1.14-4.88, p=0.021). Both acute kidney recovery (17.8%) and acute kidney injury (14.6%) following TAVR were associated with increased cardiovascular mortality compared to unchanged renal function (8.1%; p<0.022).
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