Functional characterization reveals genetic mechanisms behind early-onset diabetes, indicating complex inheritance patterns.
Functional characterization distinguishes pathogenic from variants of unknown significance and supports digenic inheritance of HNF1A and ABCC8. Their additive effects, together with intrauterine hyperglycemia, likely accelerated disease onset. This study provides mechanistic evidence for oligogenic contributions to MODY and expands the genetic architecture of early-onset diabetes.
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Honda et al. (2026) studied this question.
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