Key result
Early mechanical thrombectomy for intermediate-risk PE fails to reduce mortality vs delayed treatment but may lower intubation.
Why the study?
Does early mechanical thrombectomy (<12 hr) reduce in-hospital mortality in patients with intermediate-risk pulmonary embolism compared to delayed intervention (≥12 hr)?
Cohort (n=290)
Yes
Does early mechanical thrombectomy (<12 hr) reduce in-hospital mortality in patients with intermediate-risk pulmonary embolism compared to delayed intervention (≥12 hr)?
Odds Ratio: 1.8 (95% CI 0.82–3.95)
Absolute Event Rate: 7.3% vs 10.8%
p-value: p=0.14
In patients with intermediate-risk pulmonary embolism, early mechanical thrombectomy (<12 hours) does not significantly improve in-hospital mortality compared to delayed intervention, though it may improve pulmonary hemodynamics and reduce the need for intubation.
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Chiang et al. (2026) conducted a cohort in Intermediate-risk acute pulmonary embolism (n=290). Early mechanical thrombectomy (< 12 hr after diagnosis) vs. Delayed mechanical thrombectomy (≥ 12 hr after diagnosis) was evaluated on In-hospital mortality (OR 1.80, 95% CI 0.82-3.95, p=0.14). Early mechanical thrombectomy (<12 hours) did not significantly influence in-hospital mortality compared to delayed intervention in intermediate-risk PE (OR 1.80; 95% CI 0.82-3.95; p=0.14).
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