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April 25, 2026BMC Infectious DiseasesOpen Access

Pneumonia caused by co-infection with Mycobacterium tuberculosis and Pneumocystis jirovecii leading to acute respiratory distress syndrome in an HIV-negative immunocompromised patient: a case report and literature review

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Authors

JPJingjing PanHKHaobo KongMLMin Liang

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Overview

Case report reveals successful treatment of ARDS due to co-infection in an HIV-negative immunocompromised patient, suggesting the need for vigilant care.

Key Points

  • To report a case of pneumonia caused by co-infection with Mycobacterium tuberculosis and Pneumocystis jirovecii leading to ARDS in an HIV-negative patient.
  • Case report of a 68-year-old immunosuppressed male with pneumonia due to co-infection.
  • Metagenomic next-generation sequencing of bronchoalveolar lavage was used for diagnosis.
  • The patient received targeted anti-infective therapy and supportive respiratory care.
  • The patient showed progressive clinical improvement and was extubated on day 7 after intubation.
  • At one-month follow-up, chest CT showed substantial resolution of pulmonary lesions.
  • The successful management was attributed to timely diagnosis and effective treatment strategies.

Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/69ec5b3d88ba6daa22dacd2bhttps://doi.org/10.1186/s12879-026-13398-0
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