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April 25, 2026The journal of nutrition health & agingOpen Access

Association of dietary index for gut microbiota with premature and all-cause mortality: A mediation analysis of biological age

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Authors

AHAnwu HuangSCS ChenBLBin Lin

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Overview

Randomized trial investigates dietary index effects on mortality in adults, suggesting biological age mediates the relationship.

Key Points

  • This research examines the link between the dietary index for gut microbiota (DI-GM) and premature and overall mortality, emphasizing the role of biological age as a mediator.
  • Longitudinal study utilizing NHANES data from 2007-2018, with mortality tracking until 2019.
  • Sample size of 15,810 participants with mean age 47.0 ± 15.7 years; analyses included Cox regression and mediation analysis.
  • DI-GM scores calculated from nutritional values and linked to premature death and all-cause mortality outcomes.
  • Each one-point increase in DI-GM was associated with a 9% reduction in premature death risk (HR: 0.91, p<0.001).
  • A one-point rise in DI-GM correlated with a 10% reduction in all-cause mortality risk (HR: 0.90, p<0.001).
  • Biological age, assessed via PhenoAge, partially mediates the association between DI-GM and mortality outcomes.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69ec5b6088ba6daa22dace66https://doi.org/10.1016/j.jnha.2026.100861
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of the newly proposed dietary index for gut microbiota and all-cause and cardiovascular mortality among individuals with diabetes and prediabetes.2025 · 6 citations
  2. 2Association between the dietary index for gut microbiota (DI-GM) and all-cause mortality in older adults with COPD: Evidence from the NHANES2026
  3. 3Association between the Dietary Index for Gut Microbiota and all-cause mortality in coronary heart disease: A retrospective cohort analysis of NHANES (2005–2018)2026
  4. 4Dietary Index for Gut Microbiota, Plasma Metabolic Signature, and Risk of All-Cause and Cardiovascular Disease Mortality2026
  5. 5Dietary Index for Gut Microbiota and Risk of All-Cause and Cardiovascular Mortality Across Cardiovascular-Kidney-Metabolic Syndrome Stages 0–3: A Nationwide Prospective Cohort Study2026