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April 25, 2026Open Access

Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson's disease.

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Authors

ZSZeena ShawaCSCameron ShandBTBeatrice Taylor

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Overview

Randomized trial reveals spatiotemporal atrophy subtypes in Parkinson's disease, suggesting atrophy severity impacts clinical outcomes.

Key Points

  • This study aims to identify and characterize different patterns of brain atrophy in people with Parkinson's disease using neuroimaging data.
  • Utilized the Subtype and Stage Inference algorithm to analyze MRI data for spatiotemporal atrophy subtypes.
  • Trained models on the largest T1-weighted MRI dataset (n=1100), then tested on Parkinson's Progression Markers Initiative data (n=584).
  • Identified clinical progression and assessed differences in clinical scores among subtypes.
  • Identified three primary atrophy subtypes: Subcortical (33%), Limbic (22%), and Cortical (17%).
  • A fourth group with no significant atrophy (Sub-threshold atrophy, 29%) was also noted.
  • Statistical differences were found between the no-atrophy group and atrophy subtypes, but not among the atrophy subtypes themselves.

Cite This Study

Shawa et al. (2025) studied this question.

synapsesocial.com/papers/69ec5b6088ba6daa22dacfd6https://doi.org/10.48620/97210
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Data Driven Subtyping Reveals Two Distinctive Patterns of Deep Gray Matter atrophy and Dopamine Availability in early Parkinson’s Disease2025
  2. 2MRI subtypes in Parkinson’s disease across diverse populations and clustering approaches2024 · 17 citations
  3. 3MRI subtypes in Parkinson’s disease: Unraveling differences across diverse populations and clustering approaches2024
  4. 4Spatiotemporal Progression Patterns of Striatal Dopamine Depletion and Cerebral Hypoperfusion in Parkinson's Disease2026
  5. 5Characterization of MRI‐derived atrophy subtypes using post‐mortem MRI and neuropathological markers in Alzheimer's disease2025