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April 23, 2026Ocular Immunology and Inflammation

Immune Mediators in Birdshot Chorioretinopathy: A Systematic Review

Angel Gao Kirill Zaslavsky Yusuf Ahmed Silas Radies David Wong Brian G. Ballios Thomas Wright Panos Christakis Alexander Kaplan Nupura Bakshi Vinod Chandran Larissa Derzko-Dzulynsky

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Key Points

The aim is to explore the immune mediators involved in Birdshot chorioretinopathy (BSCR) and their implications for treatment.
Conducted a systematic review of literature on BSCR pathogenesis and treatment options.
Analyzed roles of Th17 cells, CD8+ T cells, and NK cells in disease progression and response to therapies.
Evaluated the effectiveness of anti-TNF and IL-17A inhibitors in managing BSCR.
Established the role of a Th17-mediated inflammatory response in BSCR.
Identified clinical failures of IL-17A inhibitors, indicating a need for dual IL-17A/F blockade.
Suggested future research focusing on single-cell techniques and tissue-specific insights.

Implication

Systematic review identifies immune factors in Birdshot chorioretinopathy, suggesting new treatment strategies.

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Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69ec5bd288ba6daa22dad325 https://doi.org/10.1080/09273948.2026.2655441

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Evaluation of Corticosteroids, Immunosuppressants and Biotherapies in Patients with Birdshot Retinochoroidopathy.2025
2Birdshot Chorioretinopathy in a Patient on Tocilizumab for the Treatment of Giant Cell Arteritis2025
3Pseudo-Choroidal Melanocytosis in Birdshot Chorioretinitis: A Case Series from a Prospective CohortCohort Study · 2026
4Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy2024 · 9 citations
5Visual acuity and visual field as a function of disease duration in patients with birdshot chorioretinitis2024 · 10 citations