Key result
Thyroid hormone abnormalities share bidirectional links with cardiovascular disease via endothelial dysfunction and dyslipidemia.
Why the study?
Minor alterations in thyroid hormone concentrations can affect cardiovascular physiology, and the mechanisms linking cardiovascular disease with thyroid dysfunction require synthesis for clinical understanding.
This review highlights the complex bidirectional relationship between thyroid hormone perturbations and cardiovascular disease, emphasizing the potential therapeutic role of thyroid hormones.
Highlights low triiodothyronine as a prognostic marker in cardiac disease; leaves open whether targeted thyroid.
Thyroid hormone (TH) receptors are present in the myocardium and vascular tissue, and minor alterations in TH concentration can affect cardiovascular (CV) physiology. The potential mechanisms that link CV disease with thyroid dysfunction are endothelial dysfunction, changes in blood pressure, myocardial systolic and diastolic dysfunction, and dyslipidemia. In addition, cardiac disease itself may lead to alterations in TH concentrations (notably, low triiodothyronine syndrome) that are associated with higher morbidity and mortality. Experimental data and small clinical trials have suggested a beneficial role of TH in ameliorating CV disease. The aim of this review is to provide clinicians dealing with CV conditions with an overview of the current knowledge of TH perturbations in CV disease.
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Razvi et al. (2018) conducted a review in Cardiovascular disease and thyroid dysfunction. Thyroid hormone perturbations was evaluated. Thyroid hormone perturbations are linked to cardiovascular disease through mechanisms like endothelial dysfunction and dyslipidemia, and cardiac disease itself may alter thyroid hormone concentrations.
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